The concomitant use of sertraline and monoamine oxidase inhibitors (MAOIs) should be avoided. Based on the experience of tricyclic antidepressants at least 14 days should elapse between discontinuation of MAOIs and initiation of sertraline. In patients taking ECT, sertraline administration should be avoided because of lack of experience.
Use in pregnancy: As there are no adequate and well-controlled studies in pregnant women, Zotral should be used in pregnancy only if clearly needed.
Use in lactation: It is not known whether, and if so in what amount, sertraline or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when sertraline is given to lactating mothers.
Use in children: Safety and effectiveness in children has not been established.