Quinapril is contraindicated in patients who are hypersensitive to any component of this product (i.e. quinapril hydrochloride, Magnesium carbonate, Gelatin, Lactose, Crospovidone, Magnesium stearate, Hypromellose, Hydroxypropyl cellulose, Titanium dioxide, Macrogol 400, Iron oxide red and Candelilla wax) and in patients with a history of angioedema related to previous treatment with an angiotensin-converting enzyme (ACE) inhibitor.
Quinapril is also contraindicated in women who are pregnant, intend to become pregnant, or of childbearing potential who are not using adequate contraceptive measures. Quinapril should be administered to women of childbearing age only when such patients are highly unlikely to conceive and have been informed of the potential hazards to the fetus (see Use in Pregnancy & Lactation).
Do not administer quinapril in combination with aliskiren: In patients with diabetes; in patients with moderate to severe kidney insufficiency [glomerular filtration rate (GFR) <60 mL/min/1.73 m2], hyperkalemia (>5 mmol/L); in congestive heart failure patients who are hypotensive.
Do not administer quinapril in combination with angiotensin receptor blockers or other ACE inhibitors: In diabetic patients with end organ damage; in patients with moderate to severe kidney insufficiency (GFR <60 mL/min/1.73 m2); in patients with hyperkalemia (>5 mmol/L); in congestive heart failure patients who are hypotensive.