Patients w/ mild renal or cardiac impairment; risk factors of CV disease eg, HTN, hyperlipidaemia, DM, smoking; suffering from or w/ history of bronchial asthma. Discontinue if abnormal liver function test persist or worsen &/or at the 1st appearance of skin rash, mucosal lesion or other signs of hypersensitivity. May inhibit platelet aggregation. Serious skin reaction including exfoliative dermatitis; Stevens-Johnson syndrome & toxic epidermal necrolysis. Hepatitis. Avoid during pregnancy & lactation. Not recommended in childn. Elderly.