Glimepiride is used in the treatment of type 2 diabetes mellitus (NIDDM) when diet and exercise programs fail to reduce symptoms and/or blood glucose levels. Glimepiride should be considered in addition to caloric restriction, weight loss and exercise.
Usual starting dose is 1-2 mg daily, given after the first main meal. The dose should then be titrated regularly or increased gradually, adjusting by 1-2 mg daily at intervals of 1-2 weeks, depending on the patient's response, as well as results of fasting blood sugar. Long-term efficacy is tested with a glycosylated hemoglobin assay every 3-6 months. Maintenance doses usually range from 1-4 mg per day. Maximum dose is 8 mg daily.
If the patient's hyperglycemia is not controlled with maximal doses of glimepiride, combination therapy with metformin or insulin may be considered. Frequent monitoring of blood sugar levels should be done, and the physician must strive to use the minimum doses of each drug to achieve adequate blood sugar control.
Or as prescribed by the physician.