Actimed Losartan 100 mg + Hydrochlorothiazide 25 mg

Actimed Losartan 100 mg + Hydrochlorothiazide 25 mg

losartan + hydrochlorothiazide


XL Lab




Concise Prescribing Info
Losartan K 100 mg, hydrochlorothiazide 25 mg
Essential HTN in patients whose BP is inadequately controlled on losartan or hydrochlorothiazide monotherapy.
May be taken with or without food.
Special Precautions
Pregnancy (not recommended on 1st trimester; contraindicated on 2nd & 3rd trimester) & lactation. Losartan: Patients w/ renal artery stenosis; vol depletion (eg, those on high-dose diuretic therapy). Monitor serum K conc especially in elderly & patients w/ renal impairment. Avoid concomitant use w/ K-sparing diuretics. Renal & hepatic impairment. Hydrochlorothiazide: May precipitate hyperuricemia &/or gout. Attenuated diuretic-induced hyperuricemia.
Adverse Reactions
Losartan: Dizziness, headache, dose-related orthostatic hypotension; impaired renal function; hyperkalemia, myalgia, arthralgia; resp tract disorders, back pain, GI disturbances, fatigue & neutropenia.
Drug Interactions
Losartan: Potentiated antihypertensive effects by drugs or other BP-lowering agents. Additive hyperkalaemic effect w/ K supplements, K-sparing diuretics or other drugs causing hyperkalaemia. Increased risk of renal impairment (particularly in those who are inadequately hydrated) & attenuated hypotensive effect w/ NSAIDs. Interactions w/ drugs affecting CYP450 isoenzymes. Hydrochlorothiazide: Potentiation of orthostatic hypotension w/ alcohol, barbiturates, narcotics or antidepressants. Antidiabetics eg, oral agents & insulin (may influence glucose tolerance). Risk of lactic acidosis w/ metformin.
ATC Classification
C09DA01 - losartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.
Actimed Losartan 100 mg + Hydrochlorothiazide 25 mg FC tab
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