Doxorubicin (Adriblastina RD) 10 mg Powder for Injection: Each vial contains 10 mg of doxorubicin hydrochloride.
Doxorubicin (Adriblastina RD) 50 mg Powder for Injection: Each vial contains 50 mg of doxorubicin hydrochloride.
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin consists of a naphthacenequinone nucleus linked through a glycosidic bond at ring atom 7 to an amino sugar, daunosamine. Chemically, doxorubicin hydrochloride is: 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-α-L-lyx o-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxylacetyl)-1methoxy-, hydrochloride (8S-cis)-.
Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix. The anthracycline ring is lipophilic, but the saturated end of the ring system contains abundant hydroxyl groups adjacent to the amino sugar, producing a hydrophilic center. The molecule is amphoteric, containing acidic functions in the ring phenolic groups and a basic function in the sugar amino group. It binds to cell membranes as well as plasma proteins.