Aforvir Mechanism of Action



ADP Pharma


Metro Drug


Seville Pharma
Full Prescribing Info
Pharmacology: Cetirizine hydrochloride is a long-acting antihistamine causing little or no drowsiness. It does not demonstrate any antimuscarinic activity. This drug competes reversibly with histamines which are released from mast cells. Once bound to H1 receptor sites in the tissues, cetirizine inhibits histamine-induced allergic reactions by blocking eosinophil infiltration to the site of allergen-induced cutaneous reactions.
Pharmacokinetics: Upon oral administration, Cetirizine hydrochloride is rapidly absorbed from the gastrointestinal tract. Peak plasma concentration (Cmax) is achieved after an hour Cmax of the drug may be delayed by food. However, it does not change the amount of drug absorbed. It has higher affinity to peripheral rather than central histamine H1 receptors and does not penetrate the blood-brain barrier to a significant extent.
Cetirizine hydrochloride is highly protein bound (93%) and has a half life of approximately 11 hours in adults. This is mainly excreted in the urine as unchanged drug.
Cetirizine has been detected in breast milk.
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