Adult: As 0.05% cream/oint: Apply sparingly a thin film onto the affected area 2-3 times daily, for up to 7 days. Longer duration of treatment w/ appropriate monitoring may be necessary in patients w/ resistant or chronic conditions. Child: ≥1 yr Same as adult dose. Do not use for >3 wk.
Do not apply on the face, eyes, underarm, groin, breast-fold, genitals, or between the toes.
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression thru ACTH stimulation test, plasma cortisol test, and urinary free cortisol test.
Symptom: Adrenal insufficiency/hypercorticism (e.g. Cushing’s disease). Management: Symptomatic and supportive treatment. Treat electrolyte imbalance if necessary.
Description: Alclometasone, a synthetic glucocorticoid, induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the biosynthesis and activity of prostaglandins, leukotrienes, and other inflammatory mediators. Pharmacokinetics: Absorption: Approx 3% is absorbed systemically after 8 hr when applied to intact skin. Metabolism: Extensively metabolised into polar, unidentified metabolites. Excretion: Via urine and faeces.
D07AB10 - alclometasone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
Alclometasone Dipropionate Ointment. DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 09/08/2016.Anon. Alclometasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/08/2016.Buckingham R (ed). Alclometasone Dipropionate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2016.Joint Formulary Committee. Alclometasone Dipropionate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2016.McEvoy GK, Snow EK, Miller J et al (eds). Alclometasone Dipropionate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 09/08/2016.