Aldactin 25/Aldactin 50

Aldactin 25/Aldactin 50

spironolactone

Manufacturer:

Maxtar Bio-genics

Distributor:

Zydus Healthcare Phils

Marketer:

Pharmakon
Concise Prescribing Info
Contents
Spironolactone
Indications/Uses
Primary hyperaldosteronism; edematous conditions for patients w/ CHF, cirrhosis of the liver accompanied by edema &/or ascites, nephrotic syndrome, essential HTN, hypokalemia.
Dosage/Direction for Use
Primary hyperaldosteronism Long test: 400 mg daily for 3-4 wk. Short test: 400 mg daily for 4 days. Pre-op: 100-400 mg daily. Edema in adult w/ CHF, hepatic cirrhosis or nephrotic syndrome Initially 100 mg in single or divided doses or 25-200 mg daily. Sole agent for diuresis: Continued for at least 5 days at the initial dosage level, may be adjusted to the optimal therapeutic or maintenance level administered in either single or divided daily doses. Essential HTN in adult Initially 50-100 mg in single or divided doses. Hypokalemia 25-100 mg daily.
Administration
Should be taken with food.
Contraindications
Patients w/ anuria, acute renal insufficiency, significant impairment of renal excretory function or hyperkalemia.
Special Precautions
Fluid or electrolyte imbalance eg, hypomagnesemia, hyponatremia, hypochloremic alkalosis & hyperkalemia. Determine serum & urine electrolyte in vomiting patients. Hyperkalemia may occur in patients w/ impaired renal function or excessive K intake & can cause cardiac irregularities. Reversible hyperchloremic metabolic acidosis. Dilutional hyponatremia. Gynecomastia. Pregnancy & lactation. Childn.
Adverse Reactions
Gastric bleeding, ulceration, gastritis, diarrhea & cramping, nausea, vomiting; gynecomastia, inability to achieve or maintain erection, irregular menses or amenorrhea, post-menopausal bleeding; carcinoma of the breast; agranulocytosis; fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis; mental confusion, ataxia, headache, drowsiness, lethargy; cholestatic/hepatocellular toxicity; renal dysfunction (including renal failure).
Drug Interactions
Severe hyperkalemia w/ ACE inhibitors. Potentiation of orthostatic hypotension w/ alcohol, barbiturates or narcotics. Hypokalemia w/ corticosteroids, ACTH. Reduces the vascular responsiveness to norepinephrine. Increase muscle relaxant responsiveness w/ tubocuranine. Reduce renal clearance & increase toxicity of lithium. Reduce diuretic, natriuretic, and antihypertensive effect of loop, K-sparing & thiazide diuretics w/ NSAIDs. Digitalis toxicity w/ digoxin.
MIMS Class
ATC Classification
C03DA01 - spironolactone ; Belongs to the class of aldosterone antagonists. Used as potassium-sparing diuretics.
Presentation/Packing
Form
Aldactin 25 tab 25 mg
Packing/Price
100's
Form
Aldactin 50 tab 50 mg
Packing/Price
100's
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