Essential HTN Adult 50-100 mg/day.
Difficult or severe cases May be gradually increased at intervals of 2-wk up to 200 mg/day.
CHF Initially 100 mg single or divided doses or 25-200 mg daily.
Severe heart failure in conjunction w/ standard therapy (NYHA class III-IV) Patient w/ serum K ≤5.0 mEq/L & serum creatinine ≤2.5 mg/dL 25 mg once daily. May be increased to 50 mg once daily if tolerated. Patients who do not tolerate 25 mg/day may have their dose reduced to 25 mg every other day.
Cirrhosis 100 mg/day in patient w/ urinary Na+/K+ ratio >1.0 & 200-400 mg/day.
Nephrotic syndrome 100-200 mg/day.
Edema in childn Initially 3 mg/kg daily in divided doses. Maintenance: Reduce to 1-2 mg/kg.
Diagnosis & treatment of primary hyperaldosteronism Long test: 400 mg/day for 3-4 wk. Short test: 400 mg/day for 4 days.
Short-term pre-op treatment of primary hyperaldosteronism 100-400 mg daily in prep for surgery.
Hypokalemia/hypomagnesemia 25-100 mg daily.
Management of hirsutism 100-200 mg/day, preferably in divided doses.
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