The concomitant use of donepezil hydrochloride and other cholinesterase inhibitors should be avoided.
Donepezil hydrochloride and/or its metabolites do not inhibit the metabolism of theophylline, warfarin, cimetidine, digoxin, thioridazine, risperidone and sertraline in human.
Donepezil hydrochloride is not affected by its concomitant use with digoxin, cimetidine, thioridazine, risperidone and sertraline.
The enzyme inducers like rifampicin, carbamazepine and alcohol may decrease the donepezil levels. Since the significance of the inhibitory or inducing effect is not known, such drug combinations should be used with care.
Donepezil hydrochloride has a potential to interact with medicines with anticholinergic activity. There is also a potential of synergistic activity in concomitant treatments with medicines with succinylcholine, other agents blocking neuromuscular end plate or cholinergic agonists or beta blockers having effects on cardiac conduction.