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Experience with amisulpride in overdosage is limited. There have been reports of exaggeration of the known pharmacological and adverse effects of amisulpride. Symptoms include drowsiness, sedation, coma, hypotension and extrapyramidal symptoms.
Fatal outcomes have been reported mainly in combination with other psychotropic agents. In cases of acute overdosage, the possibility of multiple drug intake should be considered.
There is no specific antidote to amisulpride. Appropriate supportive measure should be instituted with close observation of vital functions including continuous cardiac monitoring because of the risk of prolongation of QT interval. If severe extrapyramidal symptoms occur, anticholinergic agents should be administered.
Hemodialysis is not recommended as a method of elimination since amisulpride is weakly dialyzed.
