Amloval 80/5/Amloval 160/5/Amloval 160/10

Amloval 80/5/Amloval 160/5/Amloval 160/10

amlodipine + valsartan




Concise Prescribing Info
Amloval 80/5 Valsartan 80 mg, amlodipine besilate 5 mg. Amloval 160/5 Valsartan 160 mg, amlodipine besilate 5 mg. Amloval 160/10 Valsartan 160 mg, amlodipine besilate 10 mg
Essential HTN; patients whose BP is not adequately controlled on valsartan or amlodipine monotherapy.
May be taken with or without food.
Hypersensitivity to valsartan, amlodipine or dihydropyridine derivatives. Biliary cirrhosis or cholestasis; patients undergoing dialysis; severe hepatic & renal impairment (GFR <30 mL/min/1.73 m2). Pregnancy (2nd & 3rd trimesters).
Special Precautions
Na- &/or vol-depleted patients; patients w/ bilateral renal artery stenosis or stenosis to a solitary kidney & recent kidney transplantation. Primary hyperaldosteronism, heart failure, aortic & mitral valve stenosis, obstructive hypertrophic cardiomyopathy. Concomitant use w/ K supplements, K-sparing diuretics, salt substitutes containing K or other products containing K. Mild to moderate hepatic impairment or biliary obstructive disorders. Monitor K levels & creatinine in moderate renal impairment. Pregnancy (1st trimester) & lactation. Childn & adolescent. Elderly ≥65 yr.
Adverse Reactions
Nasopharyngitis, influenza; headache; edema, pitting, facial & peripheral edema, fatigue, flushing, asthenia, hot flush. Amlodipine: Vomiting.
Drug Interactions
Valsartan: Reversible increases in serum conc & toxicity of lithium. Monitor K plasma levels when given w/ K-sparing diuretics, K supplements, salt substitutes containing K & other substances that may increase K levels. Attenuation of antihypertensive effect w/ NSAIDs (including selective COX-2 inhibitors, acetylsalicylic acid (>3 g/day & nonselective NSAIDs). May increase antihypertensive effects w/ TCAs & α-blockers. Amlodipine: Inhibits metabolism w/ diltiazem. May increase plasma conc w/ CYP3A4 inhibitors ie, ketoconazole, itraconazole, ritonavir. Reduced plasma conc w/ CYP3A inducers [anticonvulsants (eg, carbamazepine, phenobarb, phenytoin, fosphenytoin, primidone), rifampicin, H. perforatum].
MIMS Class
Angiotensin II Antagonists / Calcium Antagonists
ATC Classification
C09DB01 - valsartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
Amloval 160/10 FC tab
30's (P1,260/box)
Amloval 160/5 FC tab
30's (P990/box)
Amloval 80/5 FC tab
30's (P1,260/box)
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