Ampholip Adverse Reactions

amphotericin b


BSV Bioscience Phils


Full Prescribing Info
Adverse Reactions
Patients in whom significant renal toxicity was observed following conventional amphotericin B frequently did not experience similar effects when Ampholip was substituted. Adverse reactions related to the administration of Ampholip have generally been mild to moderate and have been most prevalent during the first 2 days of dosing.
Premedication (eg, paracetamol) may be administered for the prevention of infusion-related adverse events. The most common clinical adverse effects have been chills, fever, nausea and vomiting, which may occur during the first 2 days of treatment.
Decline in renal function, shown by increased serum creatinine, azotemia and hypokalemia, have not typically required discontinuation of treatment. Ampholip has not been reported to directly cause changes in hepatic or hematologic function.
Adverse reactions that have been reported to occur with conventional amphotericin B may occur in Ampholip. In general, the physician should monitor the patient for any type of adverse event associated with conventional amphotericin B.
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