Nephrotoxic Drugs: Amphotericin B is potentially nephrotoxic and particularly close monitoring of renal function is required in patients receiving nephrotic drugs concomitantly.
Zidovudine: In dogs, exacerbated myelotoxicity and nephrotoxicity were observed when Ampholip was administered concomitantly with zidovudine. If concomitant treatment with zidovudine is required, renal and hematologic function should be closely monitored.
Cyclosporin: Preliminary data suggest that patients receiving Ampholip concomitantly with high dose of cyclosporin experience an increase in serum creatinine. The data also suggest that the increase in serum creatinine is caused by cyclosporin and not by Ampholip.
Conventional amphotericin B has been reported to interact with antineoplastic agents, corticosteroids and corticotrophin (ACTH), digitalis glycosides and skeletal muscle relaxants.