Ampicillin + sulbactam is generally well tolerated with the frequency of adverse event similar to those reported when ampicillin is given alone.
Body as a whole:
anaphylactoid reaction and anaphylactic shock.
diarrhea, nausea, vomiting, flatulence, abdominal discomfort or distention, rectal bleeding and glossitis, gastritis, stomatitis, black or "hairy" tongue, enterocolitis, pseudomembranous colitis.
headache, dizziness, confusion, changes in smell or taste perception, rare reports of convulsions.
urine retention, dysuria, increased blood urea nitrogen (BUN) and creatinine, presence of RBC's and hyaline casts in urine.
bilirubinemia, abnormal hepatic function and jaundice.
increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, and lactate dehydrogenase (LDH); decreased hemoglobin, hematocrit, RBC, WBC, neutrophils, lymphocytes, platelets and increased lymphocytes, monocytes, basophils, eosinophils and platelets; decreased serum albumin and total proteins; agranulocytosis; positive direct Coombs' Tests.
Dermatologic and Sensitivity reactions:
rash, itching, other skin reactions, Stevens-Johnson syndrome, epidermal necrolysis, urticaria, pruritus, dry skin, erythema, erythema multiforme, exfoliative dermatitis.
pain at injection site, phlebitis, thrombophlebitis, and inflammation at the injection site.
fatigue, malaise, chest pain or tightness, edema, facial swelling, chills, throat tightness, substernal pain, epistaxis and mucosal bleeding, acute hyperpyrexia (oral temperatures of up to 40°C), rapid defervescence after completion of the infusion, candidiasis.