Anazole

Anazole

anastrozole

Manufacturer:

UNILAB, Inc

Distributor:

UNILAB, Inc
Concise Prescribing Info
Contents
Anastrozole
Indications/Uses
1st-line treatment of postmenopausal women w/ hormone receptor +ve or hormone receptor unknown locally advanced or metastatic breast cancer. Advanced breast cancer in postmenopausal women w/ disease progression after tamoxifen therapy. Adjuvant treatment of postmenopausal women w/ hormone receptor +ve early breast cancer.
Dosage/Direction for Use
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Premenopausal women. Severe renal failure; moderate or severe hepatic failure. Concomitant use of selective estrogen receptor modulators & other aromatase inhibitors. Pregnancy & lactation. Childn.
Special Precautions
Postmenopausal women at high risk for osteoporosis. Monitor serum lipoprotein conc for long-term therapy. Patients w/ osteoporosis or osteopenia. May impair ability to drive or operate machinery. Childn <18 yr.
Adverse Reactions
CV, genitourinary, musculoskeletal, GI, resp, CNS, dermatologic, hepatic & hematologic effects. Wt loss/gain, cataracts, asthenia, nonspecific pain, chest pain (nonspecific), flu syndrome, accidental injury, lethargy, fever & malaise.
Drug Interactions
Selective estrogen receptor modulators (eg, tamoxifen, raloxifene) & aromatase inhibitors (eg, exemestane, formestane, letrozole). Action may be diminished by estrogens. May inhibit in vitro metabolic reactions catalyzed by cytochrome P-450 isoenzymes 1A2, 2C8/9 & 3A4 (but only at high conc).
ATC Classification
L02BG03 - anastrozole ; Belongs to the class of enzyme inhibitors. Used in treatment of neoplastic diseases.
Presentation/Packing
Form
Anazole tab 1 mg
Packing/Price
28's (P4,620/pack)
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