The following represent occurrences observed in clinical studies of angina patients. In many cases, the relationship to diltiazem has not been established. The most common occurrences from these studies as well as their frequency of presentation are: Edema (2.4%), headache (2.1%), nausea (1.9%) dizziness (1.5%), rashes (1.3%), asthenia (1.2%). Ankle edema, hypotension, flushing and gastrointestinal disturbances (including anorexia, vomiting, constipation or diarrhea, taste disturbances and weight gain) may occur. Rashes, possibly due to hypersensitivity, are normally mild and transient, but in a few cases, erythema multiforme or exfoliative dermatitis has developed. Transient elevations in liver enzyme values, and occasionally hepatitis, have been reported.
The following events were reported infrequently (<1%):
Cardiovascular: Angina, arrhythmia, AV block (1st degree), AV block (2nd or 3rd degree, see Warnings), bradycardia, bundle-branch block, congestive heart failure, ECG abnormality, flushing, hypotension, palpitations, syncope.
CNS: Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, insomnia, nervousness, paresthesia, personality change, somnolence, tremor.
Gastrointestinal: Anorexia, constipation, diarrhea, dysgeusia, dyspepsia, mild elevations of alkaline phosphatase, SGOT, SGPT and LDH.
Dermatological: Petechiae, photosensitivity, pruritus, urticaria.
Others: Amblyopia, CPK elevation, dry mouth, dyspnea, epistaxis, eye irritation, hyperglycemia, hyperuricemia, impotence and muscle cramps, nasal congestion, nocturia, osteoarticular pain, polyuria, sexual difficulties, tinnitus.