Metro Drug
Concise Prescribing Info
Amiodarone HCl
Life-threatening recurrent ventricular arrhythmias, including arrhythmias associated w/ Wolf-Parkinson-White syndrome. Prevention of arrhythmias in patients w/ MI or heart failure.
Dosage/Direction for Use
Initially 200 mg tid for a wk, then 200 mg bid for a wk, & then maintenance dose of ≤200 mg/day. Loading dose: 800-1,600 mg/day for 1-3 wk until initial therapeutic response occurs. Reduce to 600-800 mg/day for 1 mth if adequate control is achieved or side effects become prominent & then maintenance dose of 400 mg/day.
May be taken with or without food: Take consistently w/ or w/o meals. Take w/ meals if high dose or to reduce GI discomfort.
Hypersensitivity. Severe sinus node dysfunction, causing marked sinus bradycardia; 2nd- & 3rd-degree AV block; bradycardia-induced syncope.
Special Precautions
Not to be given in patients w/ bradycardia, SA block, AV block or other severe conduction disorders (unless patient has a pacemaker), severe resp failure. Heart failure. Correct electrolyte disorders before starting treatment. Avoid in patients w/ iodine sensitivity or evidence of history of thyroid disorders; exposure to sunlight.
Adverse Reactions
Severe bradycardia, sinus arrest, & conduction disturbances; severe hypotension; ventricular tachyarrhythmias; severe pulmonary toxicity including pulmonary fibrosis & interstitial pneumonitis; abnormal liver function tests, cirrhosis/hepatitis.
Drug Interactions
Induced bradycardia w/ β-blockers, Ca channel blockers & other antiarrhythmics. May reduce levels w/ enzyme inducers eg, rifampicin & phenytoin. Higher plasma conc of ciclosporin, clonazepam, digoxin, flecainide, phenytoin, procainamide, quinidine, simvastatin, warfarin. Phenothiazine, antipsychotics, TCA, halofantrine, terfenadine; HIV-PIs, cimetidine, grapefruit juice.
MIMS Class
ATC Classification
C01BD01 - amiodarone ; Belongs to class III antiarrhythmics.
Anoion tab 200 mg
50's (P39.39/tab)
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