The adverse effects reported frequently include headache, dizziness, asthenia/fatigue. Other effects include first dose hypotension, skin rash, oedema, transient elevation of liver enzymes, hyperkalemia and taste disturbances. According to clinical trials, albeit cough has not been reported as a specific drug-related event with Losartan potassium, the incidence of cough experienced is comparable to that of placebo. The adverse effects frequently experienced with Hydrochlorothiazide include electrolyte imbalance, glycosuria, hyperglycaemia, hyperuricemia and weakness. Other side effects include gastrointestinal disturbances, headaches, dizziness, photosensitivity reactions, postural hypotension, paresthesia, impotence, xanthopsia, hypersensitivity, cholestatic jaundice, pancreatitis and blood dyscrasias. Hypokalemia may be produced by hydrochlorothiazide.