Lagundi (five-leaved chaste tree) powdered leaves (Vitex negundo).
Ascof for Kids: Each tablet contains powdered lagundi 300 mg.
Each 5 mL (teaspoonful) of syrup contains the extract from Vitex negundo L. (Dried Lagundi leaves) 300 mg.
Ascof Forte for Adults: Each caplet contains powdered lagundi 600 mg.
Each 5 mL (teaspoonful) of syrup contains the extract from Vitex negundo L. (dried Lagundi leaves) 300 mg or 600 mg.
Morphology: Lagundi is an erect-branched shrub that grows up to 5 meters high and is found in all regions of the Philippines. Its leaves are green, palmate and composed of 5 leaflets which are pointed at both ends. The middle leaflets are larger than the others. It has small violet flowers (6 mm) and bears tiny black succulent fruits. The herbs are nurtured organically in farms untainted by synthetic chemical pesticides and fertilizers.
Ascof for Kids/Ascof Forte for Adults consist purely of dried mature leaves of lagundi, without any synthetic chemicals. These leaves are processed and manufactured into tablet form.
Phytochemical Analysis: Lagundi extract contains the following naturally-occurring pharmacologically active ingredients: Chrysoplenol-D, a smooth muscle relaxant; the antihistamines casticin, luteolin, isoorientin; and lagundinin, a newly identified iridoid.
Lagundi is also known as Vitex negundo (Family Verbenaceae).
Pharmacology: In a study conducted at the UP College of Pharmacy, lagundi extract has been proven to inhibit the release of leukotrienes (a mediator in the inflamed process) from mast cells.
Lagundi is the only extensively studied cough remedy and antiasthma herbal preparation in the Philippines. The National Integrated Research Program on Medicinal Plants (NIRPOMP) has established in both animal and human studies, the wide margin of safety and efficacy of lagundi as a cough remedy and antiasthma medicine.
Clinical Studies: Phase III double-blind placebo-controlled trial has shown bronchodilator and antitussive effects.
Numerous randomized double-blind, controlled clinical trials conducted at the PGH, UST and health centers showed that lagundi syrup is effective in relieving acute cough of moderate severity.
A meta-analysis of clinical trials on lagundi vs placebo among pediatric patients with acute cough of moderate severity demonstrated that lagundi syrup resulted in better clinical improvement compared to placebo with a Peto odds ratio of 0.05 significance level.
For the relief of mild to moderate cough due to common colds, flu and mild to moderate acute bronchitis; for relief of reversible mild to moderate bronchospasm in adults and children 2 years of age and older with obstructive airway disease such as asthma and chronic bronchitis.
Ascof for Kids: Syrup: Adult: 10 mL (2 teaspoonfuls) 3-4 times a day. Dose may be increased as needed, per physician's advice.
Children: 15 mg/kg/dose (or 0.25 mL/kg/dose) administered 3 times a day.
2-4 years old (10 to 15.5 kg): ½-1 teaspoonful 3 times a day.
4-6 years old (15.5 to 20 kg): 1 teaspoonful 3 times a day.
6-12 years old (20-40 kg): 1½-2 teaspoonfuls 3 times a day.
13 years old and above (over 40 kg): 2 teaspoonfuls 3 times a day.
Or as prescribed by the physician.
Ascof Forte for Adults: Tablet/capsule: 300-600 mg three times a day to four times daily. Children 7-12 years: 300 mg three times a day to four times daily.
Syrup: Adults: 5 mL (1 teaspoon) 3 to 4 times a day. Dose may be increased as needed, per physician's advice.
Children (13 years old and above): 5 mL (1 teaspoon) 3 times a day. Dose may be increased as needed, per physician's advice.
Children (2 years to 12 years old): As prescribed by the physician.
Shake well before using.
There are no known contraindications.
Patients with allergy to lagundi plant, to flavors such as grape or ginger. Safety among pregnant and lactating women has not been studied.
Safety among pregnant and lactating women has not been studied.
None were reported in the clinical trials of the syrup. Only mild side effects on a few patients, such as itchiness, nausea, vomiting and diarrhea without predominant complaint were reported for the tablets.
Drug interactions have not been studied.
Store at temperatures not exceeding 30°C.
R05FB02 - cough suppressants and expectorants ; Belongs to the class of other cough suppressants and expectorants. Used in the treatment of cough.
Ascof for Kids: Syr (ponkan/strawberry flavor) (sachet) 300 mg/5 mL x 10 mL x 60's, (grape/ponkan/strawberry flavor) (bottle) 60 mL, 120 mL.
Ascof Forte for Adults: Cap 600 mg x 60's, 120's. Tab 300 mg x 100's. 600 mg x 12's, 60's, 120's. Syr (menthol flavor) (sachet) 600 mg/5 mL x 5 mL x 60's, (bottle) 60 mL, 120 mL; (menthol sugar-free flavor) (sachet) 600 mg/5 mL x 5 mL x 60's, (bottle) 60 mL, 120 mL; (ginger flavor) (bottle) 600 mg/5 mL x 60 mL, 120 mL.