Because current information strongly suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital anomalies, as well as increased neonatal morbidity and mortality, most experts recommend that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible. Pioglitazone plus Glimepiride tablet should not be used during pregnancy unless the potential benefits justify the potential risk to the fetus.
There are no adequate and well-controlled studies in pregnant women with Pioglitazone plus Glimepiride tablet or its individual components. No animal studies have been conducted with the combined products in Pioglitazone plus Glimepiride tablet. The following data are based on findings in studies performed with Pioglitazone and Glimepiride individually.