Each 5 mL (1 teaspoonful) contains: Guaifenesin 50 mg, Salbutamol (as sulfate) 1 mg.
Pharmacology: Pharmacokinetics: Guaifenesin is absorbed from the gastrointestinal tract. It is metabolized and then excreted in the urine.
Salbutamol is rapidly absorbed from the gastrointestinal tract. It is subject to first-pass metabolism in the liver and possibly in the gut wall; the main metabolite is an inactive sulfate conjugate. Salbutamol is rapidly excreted in the urine as metabolites and uncharged drug, there is some excretion in the feces. The plasma half-life of salbutamol has been estimated to range from 4 to 6 hours.
Respiratory disorders complicated by bronchospasm and excessive secretion of tenacious mucus, bronchial asthma, chronic bronchitis and emphysema.
Children: 2 to 6 years old: 2.5 mL - 5 mL (½ teaspoon - 1 teaspoonful); 7 to 12 years old: 5 mL - 10 mL (1 teaspoonful - 2 teaspoonfuls).
Adult: 15 mL (1 tablespoonful).
To be taken every three to four times daily or as prescribed by a physician.
Asmaplex should not be given to patients with known history of peptic ulcer or gastritis. Its concurrent use with other xanthine derivatives is not advised.
The most common adverse reactions are gastrointestinal irritation and CNS stimulation.
Concomitant administration of salbutamol and other beta2 agonists with corticosteroids, diuretics, or xanthines increase the risk of hypokalemia, and monitoring of potassium concentrations is recommended in severe asthma, where such combination therapy is the rule.
Store at temperatures not exceeding 30°C.
R05CA10 - combinations ; Belongs to the class of expectorants. Used in the treatment of wet cough.