Body as a Whole:
Fever, hypothermia, thirst.
Dysrhythmias, hypotension, tachycardia.
Fluid and Electrolyte:
Dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis.
Dyspepsia, gastrointestinal bleeding, ulceration and perforation, nausea, vomiting, transient elevations of hepatic enzymes, hepatitis, Reye's Syndrome, pancreatitis.
Prolongation of prothrombin time, disseminated intravascular coagulation, coagulopathy, thrombocytopenia.
Acute anaphylaxis, angioedema, asthma, bronchospasm, laryngeal edema, urticaria.
Hypoglycemia (in children), hyperglycemia.
Agitation, cerebral edema, coma, confusion, dizziness, headache, subdural or intracranial hemorrhage, lethargy, seizures.
Prolonged pregnancy and labor, stillbirths, lower birth weight infants, antepartum and postpartum bleeding.
Hyperpnea, pulmonary edema, tachypnea.
Hearing loss, tinnitus. Patients with high frequency hearing loss may have difficulty perceiving tinnitus. In these patients, tinnitus cannot be used as a clinical indicator of salicylism.
Interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure.