Co-amoxiclav potassium combination is generally well-tolerated. Adverse effects are uncommon and mainly of a mild and transitory nature.The most frequently reported adverse effects are diarrhea, nausea, vomiting, indigestion, abdominal pain, skin rashes, urticaria and erythema multiforme, vaginitis, abnormal taste, headache, dizziness, tiredness and hot flushes. The incidence and severity of adverse effects, particularly nausea and diarrhea, increased with the higher recommended dose and can be minimized by administering the agent at the start of a meal.
Angioneurotic edema, anaphylaxis, serum sickness-like syndrome and hypersensitivity vasculitis have been observed. Skin rashes pruritis and urticaria have been occasionally reported. Erythema multiforme, Stevens-Johnson syndrome and less frequently bullous exfoliative dermatitis, toxic epidermal necrolysis and acute generalized exanthematous pustulosis (AGEP) have been reported.
Effects include gastritis stomatitis, glossitis, black hairy tongue and enterocolitis. Mucocutaneous candidiasis and antibiotic-associated colitis (including pseudomembranous and hemorrhagic colitis) have been reported. If gastrointestinal reactions are evident, they may be reduced by taking Auget at the start of a meal.
Hepatitis and cholestatic jaundice have been reported. Hepatic events have been reported predominantly in males or elderly patients and may be associated with prolonged treatment. Signs and symptoms usually occur during or shortly after treatment, but in some cases may not become apparent until several weeks after treatment has ceased.
Hemolytic anemia, reversible thrombocytopenia, thrombocytopenic purpura, eosinophilia, reversible leukopenia (including neutropenia or agranulocytosis) have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. Prolongations of bleeding time and prothrombin time have also been reported less frequently.
Central Nervous System Effects:
Central nervous system effects have been seen rarely. These include reversible hyperactivity, dizziness, headache and convulsion. Convulsions may occur with impaired renal function or in those receiving high doses.
Renal and Urinary Tract Disorders:
Crystalluria has been reportedly very rarely.
Superficial tooth discoloration has been reported rarely. It usually can be removed by brushing.