Augmentin/Augmentin ES

Co-amoxiclav (amoxicillin & clavulanic acid). Per Augmentin 375 mg tab Amoxicillin 250 mg, clavulanic acid 125 mg. Per Augmentin 625 mg tab Amoxicillin 500 mg, clavulanic acid 125 mg. Per Augmentin 1 g tab Amoxicillin 875 mg, clavulanic acid 125 mg. Per 5 mL of Augmentin 156.25 mg susp Amoxicillin 125 mg, clavulanic acid 31.25 mg. Per 5 mL of Augmentin 228.5 mg susp Amoxicillin 200 mg, clavulanic acid 28.5 mg. Per 5 mL of Augmentin 312.5 mg susp Amoxicillin 250 mg, clavulanic acid 62.5 mg. Per 5 mL of Augmentin 457 mg susp Amoxicillin 400 mg, clavulanic acid 57 mg. Per Augmentin 600 mg vial Amoxicillin 500 mg, clavulanate K 100 mg. Per Augmentin 1.2 g vial Amoxicillin 1 g, clavulanate K 200 mg. Per 5 mL of Augmentin ES 642.9 mg powd for oral susp Amoxicillin 600 mg, clavulanic acid 42.9 mg

Augmentin Infections of upper & lower resp tract, GUT, skin & soft tissue, bone & joint, septic abortion, puerperal sepsis, intra-abdominal sepsis, dental infection (for oral prep), female genital infections, septicemia, peritonitis & post-surgical infections; prophylaxis against infections associated w/ major surgical procedure (for IV presentations). Augmentin ES Upper resp tract infection (including ENT) eg, recurrent or persistent acute otitis media due to Strep pneumoniae, H. influenzae & Moraxella catarrhalis. Lower resp tract infections eg, lobar & bronchopneumonia typically caused by Strep pneumoniae, H. influenzae & Moraxella catarrhalis. Skin & soft tissue infections typically caused by Staph aureus & Strep pyogenes.

Augmentin tab Adult Mild to moderate infections 375 mg tid or 625 mg bid-tid or 1 g bid. Severe infections 2 times 375 mg tid or 1-2 times 625 mg tid or 1 g bid-tid. Augmentin susp Childn Skin & soft tissue infection, recurrent tonsillitis 20-40 mg/kg/day tid or 25-45 mg/kg/day bid. Otitis media, sinusitis, lower resp tract infection, UTI 40-60 mg/kg/day tid or 45-70 kg/mg/day bid. Augmentin inj By intermittent IV infusion. Adult & childn >12 yr 1.2 g 8 hrly increasing to 6 hrly in more serious infections. Childn 3 mth-12 yr 30 mg/kg 8 hrly increasing to 6 hrly in more serious infections, 0-3 mth 30 mg/kg 12 hrly in premature & full-term infants during perinatal period increasing to 8 hrly thereafter. Adult Surgical prophylaxis 1.2 g IV at induction of anesth. High risk of infection: 3-4 doses of 1.2 g IV 24 hr period. Augmentin ES susp Childn ≥3 mth 90/6.4 mg/kg/day in 2 divided doses at 12-hrly intervals for 10 days, 36 kg 13.5 mL bid, 32 kg 12 mL bid, 28 kg 10.5 mL bid, 24 kg 9 mL bid, 20 kg 7.5 mL bid, 16 kg 6 mL bid, 12 kg 4.5 mL bid, 8 kg 3 mL bid.

May be taken with or without food: Best taken at the start of meals for better absorption & to reduce GI discomfort.

Hypersensitivity to β-lactams eg, penicillins & cephalosporins. History of co-amoxiclav-associated jaundice/hepatic dysfunction.

Careful enquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins or other allergens prior to initiation of therapy. History of penicillin hypersensitivity. Discontinue & initiate alternative therapy if an allergic reaction occurs. Suspected infectious mononucleosis. Overgrowth of nonsusceptible organisms in prolonged use. Pseudomembranous colitis. Discontinue treatment if prolonged or significant diarrhea occurs or the patient experiences abdominal cramps. Concomitant use w/ anticoagulants. Ensure adequate hydration & urinary output especially w/ parenteral therapy or high doses. Hepatic dysfunction. Renal impairment. Pregnancy & lactation. Tab/susp: Perform periodic assessment of organ system functions including renal, hepatic, hematopoietic function during prolonged therapy. Phenylketonuria. Inj: Cholestatic jaundice. Patients on Na-restricted diet. False +ve Coombs' test.

Diarrhoea, nausea, vomiting (uncommon for IV powd for inj), mucocutaneous candidiasis.

Decreased renal tubular secretion w/ probenecid. Increased allergic skin reactions w/ allopurinol. May affect the gut flora leading to lower estrogen reabsorption & reduced efficacy of combined OCs. Increased INR w/ acenocoumarol or warfarin, mycophenolate mofetil, methotrexate.

Penicillins

J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Rx