Augmentin/Augmentin ES

Augmentin/Augmentin ES Caution For Usage

amoxicillin + clavulanic acid




Full Prescribing Info
Caution For Usage
Augmentin: Incompatibilities: Injection: Co-amoxiclav (Augmentin) intravenous should not be mixed with blood products, other proteinaceous fluids such as protein hydrolysates or with intravenous lipid emulsions.
If Co-amoxiclav (Augmentin) is prescribed concurrently with an aminoglycoside, the antibiotics should not be mixed in the syringe, intravenous fluid container or giving set because loss of activity of the aminoglycoside can occur under these conditions.
Instructions for Use and Handling: For sachet, contents should be stirred into water before taking.
Tablet/Powder for Suspension: For administration of suspensions to children below 3 months, a syringe graduated to permit accurate and reproducible volumes to be dispensed, should be used.
For administration to children up to 2 years, co-amoxiclav suspensions may be diluted to half-strength using water.
Injection: 600-mg Vial: To reconstitute dissolve in 10 mL Water for Injections BP. (Final volume 10.5 mL)
1.2-g Vial: To reconstitute dissolve in 20 mL Water for Injections BP. (Final volume 20.9 mL)
A transient pink coloration may or may not appear during reconstitution. Reconstituted solutions are normally colourless or a pale, straw colour.
Intravenous Injection: The stability of Co-amoxiclav (Augmentin) intravenous solution is concentration dependent, thus Co-amoxiclav (Augmentin) intravenous should be used immediately upon reconstitution and given by slow intravenous injection over a period of 3-4 minutes. Co-amoxiclav (Augmentin) intravenous solutions should be used within 20 minutes of reconstitution. Co-amoxiclav (Augmentin) may be injected directly into a vein or via a drip tube.
Intravenous Infusion: Alternatively, Co-amoxiclav (Augmentin) intravenous may be infused in Water for Injections BP or Sodium Chloride Intravenous injection BP (0.9% w/v). Add, without delay*, 600 mg reconstituted solution to 50 mL infusion fluid or 1.2 g reconstituted solution to 100 mL infusion fluid (e.g. using a minibag or in-line burette). Infuse over 30-40 minutes and complete within four hours of reconstitution. For other appropriate infusion fluids, see Stability and Compatibility as follows.
*Solutions should be made up to full infusion volume immediately after reconstitution.
Any residual antibiotic solutions should be discarded.
Therapy can be started parenterally and continued with an oral preparation. Treatment should not be extended beyond 14 days without review.
Infant Drops: First shake the bottle to loosen the powder. Water should be added until the fill line on the bottle label, and then shake the bottle well. Then top up with water until the level of the fill line is reached and shake again. When first reconstituted, allow to stand for 5 minutes to ensure full dispersion.
The device is used to dose patient under 2 years according to the schedule (see Dosage & Administration).
Shake bottle before use.
Insert pipette into adaptor, ensure firmly located.
Invert bottle and withdraw required dose.
Place bottle upright and remove pipette from adaptor.
Rinse pipette in clean water.
Replace bottle cap.
Stability and Compatibility: Intravenous infusions of Co-amoxiclav (Augmentin) may be given in a range of different intravenous fluids. Satisfactory antibiotic concentrations are retained at 5°C and at room temperature (25°C) in the recommended volume of the following infusion fluids. If reconstituted and maintained at room temperature, infusions should be completed within the times stated. (See Table 10.)

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Reconstituted solutions should not be frozen.
Co-amoxiclav (Augmentin) is less stable in infusions containing glucose, dextran or bicarbonate. Reconstituted solutions of Co-amoxiclav (Augmentin) should therefore not be added to such infusions but may be injected into the drip tubing over a period of 3-4 minutes.
For storage at 5°C, the reconstituted solution should be added to pre-refrigerated infusion bags which can be stored for up to 8 hours. Thereafter, the infusion should be administered immediately after reaching room temperature. (See Table 11.)

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Augmentin ES: At time of dispensing, the dry powder should be reconstituted to form an oral suspension, as detailed as follows: Check cap seal is intact before use.
Invert and shake bottle to loosen powder.
Fill the bottle with water to just below the mark on bottle label. Invert and shake well, then top up with water to the mark. Invert and shake again.
Shake well before taking each dose.
Each teaspoonful (5 mL) will contain 600 mg amoxicillin as the trihydrate and 42.9 mg of clavulanate as the potassium salt.
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