Sensitization may recur when re-administered irrespective of the route of administration. Discontinue if signs of serious reactions or hypersensitivity occurs. Acute-angle closure glaucoma. Severe renal & hepatic impairment. Concomitant administration w/ oral carbonic anhydrase inhibitors. Ocular surgery or intercurrent ocular condition eg, trauma or infection. If >1 topical ophth drug is being used, administer atleast 10 min apart. Contains benzalkonium Cl. Remove contact lenses prior to application & wait at least 15 min before reinsertion. May impair ability to drive & operate machinery. Pregnancy & lactation. Childn.