Wash hands before and after each application unless mupirocin is used to treat a hand condition.
Clean the affected and adjacent area with mild soap and water.
Rinse thoroughly and pat dry.
Apply a small amount of mupirocin ointment on the affected area three times daily for up to 10 days, or as prescribed by a physician. The treated area may be covered with gauze dressing if needed.
Re-assess patients not showing a clinical response within 3 to 5 days.
Do not apply concurrently with other topical medications, as there is a potential risk of dilution, resulting in reduction in antibacterial activity and potential loss of stability of mupirocin.