Not to exceed 2 MAC·hr at flow rates 1 to <2 L/min. Not recommended at fresh gas flow rates of <1 L/min. Renal insufficiency (creatinine >1.5 mg/dL). Glycosuria & proteinuria at low flow rates. Known sensitivity to volatile halogenated anesth agents. Not recommended in concomitant use w/ KOH containing CO2 absorbents. Patients w/ congenital long QT syndrome or taking QT interval-prolonging drugs; underlying hepatic conditions or under treatment of drugs known to cause hepatic dysfunction. Malignant hyperthermia. Perioperative hyperkalemia especially in patients w/ latent & overt neuromuscular disease, particularly Duchenne muscular dystrophy. Seizures. Severe hepatic dysfunction. Pregnancy. Ped patients <1 yr. Elderly.