Pharmacology: Mechanism of Action: Tablet: Bee-All Tablet is a combination of 3 essential neurotropic vitamins (B1, B6 and B12) in high dosage.
Vitamins B1, B6 and B12 are of special importance for the metabolism in the peripheral and central nervous system. Their effect on the regeneration of nerves has been shown in various investigations using the vitamins individually and in combination.
Vitamin B1 plays an important role in major metabolic processes. Vitamin B6 has an analgesic effect. Vitamin B12 ensures blood cell formation and prevents degenerative processes of the nervous system.
Both the individual function and the beneficial biochemical links between the 3 vitamins justify their combined use.
Solution for injection: Vitamin B1 acts as a coenzyme in α-keto acids decarboxylation and involved in carbohydrate metabolism.
Vitamin B6 in the body is converted into pyridoxal phosphate and pyridoxamine phosphate that can help protein and amino acid metabolism.
Vitamin B12 plays an important role in nucleic acid synthesis and cell formation, and influence in the maintenance of nerve tissue integrity.
Pharmacokinetics: It is widely absorbed to most body tissues, and appears in breast milk. Vitamin B1 is not stored to any appreciable extent in the body and amounts in excess of the body's requirements are excreted in the urine unchanged or as metabolites.
Solution for injection: Vitamin B1 is rapidly absorbed on intramuscular injection.
Vitamin B6 is readily absorbed from the gastrointestinal tract after oral doses and are converted to the active form pyridoxal phosphate and pyridoxamine phosphate. They are stored mainly in the liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites which are excreted in the urine.
Vitamin B12 substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract.
Vitamin B12 is extensively bound to specific plasma called transcobalamins, transcobalamin II appears to be involved in the rapid transport of the cobalamins to tissues. Vitamin B12 is stored in the liver, excreted in the bile, and undergoes extensive enterohepatic recycling: part of a dose is excreted in the urine most of it in the first 8 hours; urinary excretion, however, accounts for only a small fraction in the reduction of total body stores acquired by dietary means, vitamin B12 diffuses across the placenta and also appears in breast milk.