Prosweal Healthcare


Prosweal Healthcare
Full Prescribing Info
Vitamin B-complex.
Tablet: See Table 1.

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Excipients/Inactive Ingredients: Lactose, Polyvidone (PVP), Microcrystalline Cellulose, Gelatine 250 Bloom, Croscarmellose Sodium, Sodium Starch Glycolate, Magnesium Stearate, Talc, Ethanol, Purified Water, Dichloromethane, FDC Red No. 3 Al-Lake, FDC Red No. 40 Al-Lake, Opadry, and Opaglos.
Solution for Injection:
See Table 2.

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Pharmacology: Mechanism of Action: Tablet: Bee-All Tablet is a combination of 3 essential neurotropic vitamins (B1, B6 and B12) in high dosage.
Vitamins B1, B6 and B12 are of special importance for the metabolism in the peripheral and central nervous system. Their effect on the regeneration of nerves has been shown in various investigations using the vitamins individually and in combination.
Vitamin B1 plays an important role in major metabolic processes. Vitamin B6 has an analgesic effect. Vitamin B12 ensures blood cell formation and prevents degenerative processes of the nervous system.
Both the individual function and the beneficial biochemical links between the 3 vitamins justify their combined use.
Solution for injection: Vitamin B1 acts as a coenzyme in α-keto acids decarboxylation and involved in carbohydrate metabolism.
Vitamin B6 in the body is converted into pyridoxal phosphate and pyridoxamine phosphate that can help protein and amino acid metabolism.
Vitamin B12 plays an important role in nucleic acid synthesis and cell formation, and influence in the maintenance of nerve tissue integrity.
Pharmacokinetics: It is widely absorbed to most body tissues, and appears in breast milk. Vitamin B1 is not stored to any appreciable extent in the body and amounts in excess of the body's requirements are excreted in the urine unchanged or as metabolites.
Solution for injection: Vitamin B1 is rapidly absorbed on intramuscular injection.
Vitamin B6 is readily absorbed from the gastrointestinal tract after oral doses and are converted to the active form pyridoxal phosphate and pyridoxamine phosphate. They are stored mainly in the liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites which are excreted in the urine.
Vitamin B12 substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract.
Vitamin B12 is extensively bound to specific plasma called transcobalamins, transcobalamin II appears to be involved in the rapid transport of the cobalamins to tissues. Vitamin B12 is stored in the liver, excreted in the bile, and undergoes extensive enterohepatic recycling: part of a dose is excreted in the urine most of it in the first 8 hours; urinary excretion, however, accounts for only a small fraction in the reduction of total body stores acquired by dietary means, vitamin B12 diffuses across the placenta and also appears in breast milk.
Neurological and other disorders associated with disturbance of the metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post-influenzal neuropathies.
For the treatment of neuritis and neuralgias of the spinal nerves, especially facial paresis, cervical syndrome, low back pain, ischialgia.
Dosage/Direction for Use
Tablet: Dosage: 1 tablet 3 times daily to treat moderate cases, or to provide interval and follow-up therapy for a course of injections.
The duration of the treatment is determined by the physician.
Administration: Swallow without chewing with a little liquid with or after meals.
Solution for injection: Initially one (1) ampule daily given by intramuscular injection (intragluteal) then 2-3 ampules weekly or as prescribed by the physician.
Prolonged overdose of vitamin B6 in other word for more than 2 months and more than 1 g per day, may lead to neurotoxic effects.
Hypersensitivity to any of the active or excipients of Bee-All (see Description).
Use in children: Bee-All Tablet and Injection are not suitable for the treatment of children due to the high content of active ingredients.
Special Precautions
Tablet: In the literature, neuropathies are described under long-term intake (6-12 months) of more than 50 mg mean daily dose of vitamin B6. Therefore, under long-term treatment regular monitoring is recommended.
Bee-All Tablet contains lactose and sucrose, therefore its use is not recommended in patients with intolerance to some sugars (in other word rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency or sucrose-isomaltase insufficiency).
Use In Pregnancy & Lactation
Tablet: No risks have become known associated with the use of Bee-All Tablet during pregnancy at the recommended dosage.
Vitamins B1, B6 and B12 are secreted into human breast milk, but risks of overdose for the infant are not known. In individual cases, high doses of vitamin B6 in other word more than 600 mg daily may inhibit the production of breast milk.
Adverse Reactions
Tablet: Hypersensitivity reactions to vitamin B1 or B12 eg, sweating, tachycardia (rapid heartbeat) and skin reactions with itching and urticaria may occur. Gastrointestinal complaints eg, nausea, vomiting, diarrhoea or abdominal pain may occur.
Drug Interactions
Tablet: Levodopa (L-Dopa): The effect of L-dopa may be reduced when vitamin B6 is administered concomitantly.
Pyridoxine-Antagonists eg, Isoniazid (INH), Cycloserine, Penicillamine, Hydralazine: The efficacy of vitamin B6 (Pyridoxine) may be decreased.
Loop Diuretics eg, Furosemide: In long-term use, the blood level of thiamine may be reduced.
Store at temperatures not exceeding 30°C.
ATC Classification
A11DB - Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.
FC tab 100's. Soln for inj (amp) 3 mL x 20's.
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