Cetirizine HCl, though considered as nonsedating antihistamine, was found to cause drowsiness in some people.
Recurrent acute hepatitis developed in 1 patient taking cetirizine HCl for control of seasonal allergic rhinitis.
Other adverse effects associated with the use of cetirizine HCl are irritability, insomnia, somnolence, fatigue, dry mouth, pharyngitis, dizziness, headache, abdominal pain, cough, diarrhea, epistaxis, bronchospasm, nausea and vomiting, and hypersensitivity manifested by urticaria and fixed drug eruptions.
Although cetirizine HCl has low potential for severe hepatotoxicity, the possibility of developing autoimmune-mediated hepatotoxicity should be considered when administering the drug. A patient under long-term treatment with cetirizine HCl for atopic dermatitis was reported to have developed life-threatening hepatitis.