Starting and Maintenance Dose: 25 or 50 mg once daily for most patients with or without food. The maximal antihypertensive effect is attained 3-6 weeks after initiation of therapy. Some patients may receive an additional benefit by increasing the dose up to 100 mg once daily, in 1 or 2 divided doses.
Intravascular Volume Depletion: In patients who are intravascularly volume depleted (eg, those treated with high-dose diuretics), symptomatic hypotension may occur. Such a condition should be corrected prior to administration of losartan or a lower starting dose should be used.
Elderly Up to 75 years: No initial dosage adjustment is necessary for this group of patients, or as prescribed by the physician. >75 years: At present there is limited clinical experience in this group; a lower starting dose of 25 mg once daily is recommended.
Renal Impairment: No initial dosage adjustment is necessary in patients with mild renal impairment ie, creatinine clearance (CrCl) 20-50 mL/min. For patients with moderate to severe renal impairment ie, CrCl <20 mL/min or patients on dialysis, lower starting dose of 25 mg once daily is recommended.