Clinical effects: Note: The following symptoms describe overdose of nonsteroidal anti-inflammatory drugs (NSAIDs) in general. Anaphylactoid reaction; cardiac arrest; convulsions; drowsiness; lethargy; epigastric pain; gastrointestinal bleeding; hepatic dysfunction; hypertension; nausea or vomiting; acute renal failure; respiratory depression.
Treatment of overdose: Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding. Patients should be managed with symptomatic and supportive care, possibly including: To decrease absorption: Activated charcoal - recommended for patients who present 1 to 2 hours after overdose; Cholestyramine; Gastric lavage - if performed within one hour of overdose. Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation.