Edema, neoplasm, cyst, hernia, infection, fever, chills, sepsis fatigue, and flu syndrome. Pain in the back, pelvic, chest, neck, and abdomen.
Angina pectoris, congestive heart failure, hypertension, myocardial infarction, coronary artery disorder, and hot flushes. Conduction defects including PR and QT interval prolongations, arrhythmias and non-specific ECG changes have been observed.
Anorexia, heartburn, dyspepsia, dysphagia, periodontal abscess, rectal hemorrhage, gastrointestinal cancer, dry mouth, melena, flatulence, constipation, diarrhea, nausea, and vomiting.
Breast pain and/or tenderness, gynecomastia and diabetes mellitus.
Metabolic and Nutritional:
Weight gain, dehydration, gout, peripheral edema/fluid retention, hyperglycemia, and weight loss.
Anemia, leukopenia and thrombocytopenia.
Myasthenia, asthenia, arthritis, myalgia, leg cramps, pathological fracture, bone pain.
Anxiety, headache, depression, hypertonia, somnolence, confusion, neuropathy, nervousness, dizziness, paresthesia, and insomnia.
Interstitial lung disease, increased cough, pharyngitis, bronchitis, pneumonia, asthma, epistaxis, sinusitis, rhinitis, pulmonary disorders, and dyspnea.
Immune System Disorders:
Hypersensitivity reactions, including angioneurotic edema and urticaria.
Skin and Appendages:
Pruritus, dry skin, Herpes Zoster, skin carcinoma, alopecia, rash, sweating, and hirsutism.
Jaundice and hepatic failure.
Increased urinary frequency, urinary impairment, dysuria, urinary retention, urinary urgency, nocturia, hematuria, urinary tract infection, impotence, and hydronephrosis.
Abnormal Laboratory Test Values:
Elevated aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, blood urea nitrogen (BUN), and creatinine; decreased hemoglobin and white blood cells (WBC). Elevated hepatic enzymes and decreased hemoglobin were less frequently reported.