Biocillin Plus 750

Biocillin Plus 750

ampicillin + sulbactam


BioRx Pharma Labs




Concise Prescribing Info
Ampicillin Na 500 mg, sulbactam Na 250 mg
Skin & skin structure, intra-abdominal, & gynecological infections caused by β-lactamase producing microorganisms.
Dosage/Direction for Use
Adult 750 mg to 3 g every 6 hr. Max: 4 g/day. Childn ≥1 yr 300 mg/kg IV infusion in equally divided doses every 6 hr. Renal impairment CrCl ≥30 mL/min/1.73 m2 0.75-3 g every 6-8 hr, 15-29 mL/min/1.73 m2 0.75-3 g every 12 hr, 5-14 mL/min/1.73 m2 0.75-3 g every 24 hr.
Special Precautions
Previous hypersensitivity reactions to penicillins, cephalosporins, & other allergens. C. difficile associated diarrhea. Patient w/ mononucleosis. Possibility of superinfections w/ mycotic or bacterial pathogens during therapy. Discontinue if superinfections occur. Pregnancy & lactation.
Adverse Reactions
Pain at IM/IV inj site, thrombophlebitis; diarrhea, rash; decreased Hb, hematocrit, RBC, WBC, neutrophils, lymphocytes, platelets & increased lymphocytes, monocytes, basophils, eosinophils & platelets; decreased serum albumin & total proteins; increased BUN & creatinine; presence of RBC's & hyaline casts in urine. Gastritis, stomatitis, black "hairy" tongue & enterocolitis; urticaria, erythema multiforme, exfoliative dermatitis; agranulocytosis. +ve Coombs' test.
Drug Interactions
Decreased renal tubular secretion & increased/prolonged blood levels w/ probenecid. Ampicillin: Increased incidence of rashes w/ allopurinol. In vitro inactivation of aminoglycosides.
MIMS Class
ATC Classification
J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Biocillin Plus 750 powd for inj
5 mL x 1's
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