Biosulidd R/Biosulidd N/Biosulidd 30:70

Biosulidd R/Biosulidd N/Biosulidd 30:70

insulin isophane, human

Manufacturer:

MJ Biopharm

Distributor:

PNF
Concise Prescribing Info
Contents
Biosulidd R Insulin human. Biosulidd N Isophane insulin human. Per mL of Biosulidd 30:70 Insulin human 30 IU, isophane insulin human 70 IU
Indications/Uses
DM requiring insulin for the maintenance of glucose homeostasis.
Contraindications
Biosulidd R Liver problems, kidney disease, low blood sugar & low amount of K in the blood. Biosulidd N Hypersensitivity. Hypoglycemia.
Special Precautions
Reduction in dosage may be required on transfer from animal (especially beef insulin) to human insulin. Increased doses/requirements may be necessary during infection/illness, emotional stress/disturbances. Excessive exercise or changes in level of physical activity. Travelling across ≥2 time zones. Pregnancy & lactation. Biosulidd R/Biosulidd 30:70 Increased doses may be necessary during accidental or surgical trauma, puberty & latter 2 trimesters of pregnancy; decreased doses may be necessary in patients w/ impaired renal or liver function or during the 1st trimester of pregnancy. Temporary decrease in requirement may also occur following initiation & stabilization of therapy in newly-diagnosed diabetic patients. Avoid inadvertent change from insulin of one species to another. Hypoglycemia caused by metabolic effects & increased insulin absorption. Monitor blood for glucose conc & urine for ketones. Concomitant use w/ drugs which have effect on blood-glucose conc. Should not be given as IV & as treatment of diabetic ketoacidosis. Biosulidd N Transferring patient to another type or brand of insulin. Inadequate or discontinuation of treatment, especially in insulin dependent diabetics, may lead to hyperglycemia & diabetic ketoacidosis. Diseases of adrenal, pituitary or thyroid glands & in presence of renal or hepatic impairment. Changes in usual diet. Concomitant use w/ pioglitazone especially in patients w/ risk factors for development of cardiac heart failure. May affect ability to drive & use machines.
Adverse Reactions
Hypoglycemia. Lipoatrophy or lipohypertrophy. Local or systemic hypersensitivity reaction.
Drug Interactions
Biosulidd R Enhanced blood glucose-lowering effect & increased susceptibility to hypoglycemia w/ oral antidiabetic medicinal products, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates & sulphonamide antibiotics. Reduced blood glucose-lowering effect w/ corticosteroids, danazol, diazoxide, diuretics, glucagon, INH, estrogens & progestogens (eg, OCs), phenothiazine derivatives, somatropin, sympathomimetic drugs (eg, epinephrine, salbutamol, terbutaline), thyroid hormones, PIs & atypical antipsychotic medicinal products (eg, olanzapine & clozapine). May potentiate or weaken blood glucose-lowering effect w/ β-blockers, clonidine, lithium salts or alcohol. May cause hypoglycemia w/ pentamidine. Signs of adrenergic counter-regulation may be reduced or absent w/ sympatholytic medicinal products eg, β-blockers, clonidine, guanethidine & reserpine. Biosulidd N Increased insulin requirements w/ glucocorticoids, thyroid hormones, growth hormone, danazol, β2-sympatomimetics (eg, ritodrine, salbutamol, terbutaline), thiazides. Reduced insulin requirements w/ oral hypoglycemic agents, salicylates (eg, acetylsalicylic acid), MAOIs, ACE inhibitors (captopril, enalapril), angiotensin II receptor blockers, non-selective β-blocking agents & alcohol. Somatostatin analogues (octreotide, lanreotide) may both decrease or increase insulin dose requirements.
ATC Classification
A10AD01 - insulin (human) ; Belongs to the class of intermediate-acting combined with fast-acting insulins and analogues. Used in the treatment of diabetes.
A10AC01 - insulin (human) ; Belongs to the class of intermediate-acting insulins and analogues. Used in the treatment of diabetes.
A10AB01 - insulin (human) ; Belongs to the class of fast-acting insulins and analogues. Used in the treatment of diabetes.
Presentation/Packing
Form
Biosulidd R soln for inj 100 IU/mL
Packing/Price
10 mL x 1's
Form
Biosulidd N susp for inj 100 IU/mL
Packing/Price
10 mL x 1's
Form
Biosulidd 30:70 susp for inj
Packing/Price
10 mL x 1's
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