Each suppository contain: Bisacodyl 10 mg.
Pharmacology: Bisacodyl is diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation before investigational procedures or surgery. Its action is mainly in the large intestines and it is usually effective within 6 to 12 hours following administration by mouth and within 15 to 60 minutes following rectal administration.
Bisacodyl tablets should be swallowed whole and should not be taken within one hour of milk or antacids.
Pharmacokinetics: Following administration of bisacodyl by mouth or rectally, it is converted to the active desacetyl metabolite bis (p-hydroxyphenyl) pyridyl-2-methane by intestinal and bacterial enzymes. Absorption from the gastrointestinal tract is minimal with enteric-coated tablets or suppositories; the small amount. Absorbed is excreted in the urine as the glucuronide. Bisacodyl is mainly excreted in the feces.
It is used for the treatment for constipation and for bowel evacuation before investigational procedures or surgery.
For constipation, bisacodyl is given in usual doses of 5 to 15 mg daily as enteric-coated tablets administered at night or 10 mg suppository or enema administered in the morning.
Doses of 10 up to 20 mg are given by mouth for complete bowel evacuation, followed by 10 mg as suppository the next morning.
Children under 10 years age may be given 5 mg rectally in the morning for constipation; those over 4 years may alternatively be given 5 mg by mouth at night. For bowel evacuation the dose is 15 mg by mouth the night before and 5 mg rectally the morning of the procedure. Children over 10 years of age may be given doses similar to those for adults.
Bisacodyl has been administered with a barium sulfate enema before radiographic examination of the colon. A complex of bisacodyl with tannic acid (bisacodyl tannex) is generally used in a dose equivalent to 1.5 to 3 mg of bisacodyl dissolved in 1 litre of barium sulfate suspension. The total dose for one procedure should not exceed 4.5 mg bisacodyl and no more than 6 mg should be administered in 72 hours.
Bisacodyl and other stimulant laxatives may cause abdominal discomfort such as colic cramps. Prolonged used or overdosage can result in diarrhea with excessive loss of water and electrolytes, particularly potassium; there is also the possibility developing an atonic non-functioning colon.
It may cause abdominal discomfort such as colic or cramps. Prolonged use or overdosage can result in diarrhea with excessive loss of water and electrolytes, particularly potassium.
When administered rectally, sometimes causes irritation and repeated use may cause proctitis or sloughing of the epithelium.
As with other laxatives, prolonged use should be avoided. Bisacodyl should not be given to patients with intestinal obstruction or acute abdominal conditions such as appendicitis; care should also be taken in patients with inflammatory bowel disease. It should not be used in patients with severe dehydration. The suppositories should be preferably avoided in patients with anal fissures, proctitis, or ulcerated hemorrhoids.
Bisacodyl may cause abdominal discomfort such as colic or cramps. Prolonged use or overdosage can result in diarrhea with excessive loss of water and electrolytes, particularly potassium; there is also the possibility of developing an atonic nonfunctioning colon. When administered rectally bisacodyl sometimes causes irritation and repeated use may cause proctitis or sloughing of the epithelium. To avoid gastric
irritation bisacodyl tablets are enteric-coated.
A06AB02 - bisacodyl ; Belongs to the class of contact laxatives.
Supp 10 mg x 5 x 10's, 100's.