Pulmonary: Since Bleomycin can cause severe interstitial pneumonia or pulmonary fibrosis, it is necessary to make careful observations and if any change in A-aDo2, PaO2, DLco or any abnormality of the chest roentgenogram is recognized, or if clinical symptoms such as exertional dyspnea or the appearance of rales develop, administration should be immediately halted and appropriate measures must be done.
Idiosyncratic Reactions: Hypotension, mental confusion, fever, chills, and wheezing.
Integument and Mucous Membranes: These consist of erythema, rash, vesiculation, hyperpigmentation, and tenderness of the skin. Hyperkeratosis, nail changes, alopecia, pruritus, and stomatitis have also been reported.
Other: Fever, chills, and vomiting were frequently reported side effects. Anorexia and weight loss are common and may persist long after termination of this medication. Pain at tumor site, phlebitis, and other local reactions were reported infrequently.