The intensity of the adverse reactions depends on dosage and route of administration. An initial dose titration will often reduce the adverse reactions. Adverse reactions which have been recorded, e.g. tremor, headache, tonic muscle cramps, tachycardia and palpitations, are all characteristic of sympathomimetic amines. The majority of these effects have reversed spontaneously within the first 1-2 weeks of treatment.
As for all β2-agonist, cardiac arrhythmias, e.g. atrial fibrillation, supraventricular tachycardia and extrasystole have been rarely reported.
Urticaria and exanthema may occur.
Sleep disturbances and behavioural disturbances, such as agitation, hyperactivity and restlessness, have been observed.
Injection: During treatment of preterm labour, when high doses of Terbutaline sulfate (BRICANYL) are used, diabetic mothers may develop hyperglycaemia and lactacidosis. In these patients glucose and acid-base balance should be carefully monitored. High doses of β2-stimulants may cause hypokalemia as a result of redistribution of potassium. Symptoms of pulmonary edema have also been reported following treatment of preterm labour. An increased tendency to bleeding has been described in connection with caesarean section (give Propranolol, 1-2 mg i.v.) in patients treated with Terbutaline sulfate (BRICANYL) for preterm labour.