Bricanyl

Bricanyl Dosage/Direction for Use

terbutaline

Manufacturer:

AstraZeneca

Distributor:

Zuellig
Full Prescribing Info
Dosage/Direction for Use
Tablet: Terbutaline sulfate (BRICANYL) tablets should be used as maintenance therapy in asthma and other pulmonary diseases where bronchospasm is a complicating factor. Preterm labour.
Dosage should be individually titrated.
Bronchospasm: Adults: During the first 1-2 weeks 2.5 mg (1 tablet) 3 times in a 24 h period is recommended. The dose may then, if necessary, be increased to 5 mg (2 tablets) 3 times in 24 hours.
Children: 0.075 mg/kg body weight 3 times in 24 hours.
Suitable dosage: 20 kg: ¼-½ tablet 3 times in 24 hours.
20-30 kg: ½-1 tablet 3 times in 24 hours.
>30 kg: 1-2 tablets 3 times in 24 hours.
Preterm Labour: The drug must be individually titrated. Pulse rate and blood pressure should be carefully monitored during treatment. Initially 5 ug/min I.V. of Terbutaline sulfate (BRICANYL) solution for injection could be given as an infusion during 20 minutes. The dose can then be increased by 2.5 ug/min at 20 minutes intervals until contractions stop. More than 10 ug/min should seldom be given and 20 ug/min should not be exceeded. Let the infusion continue for 1 h at the chosen infusion rate, and then decrease the rate of infusion in steps of 2.5 ug/min at 20 minutes interval down to the lowest maintenance dose that produces continued suppression of the contractions. Keep the infusion at this rate for 12 h and then continue with oral maintenance therapy (5 mg x 3).
The oral treatment should be continued until the end of the 36th week of pregnancy. As an alternative treatment, subcutaneous injections (0.25 mg four times in a 24 h period) could be given for a few days before oral treatment is started.
Injection: The dose may be given intravenously or subcutaneously.
Terbutaline sulfate (BRICANYL) solution for injection, 1 mL ampoule, is intended for subcutaneous and intravenous injection.
Terbutaline sulfate (BRICANYL) solution for injection, 5 mL ampoule, is intended for infusion after dilution with infusion solutions.
Dosage should be individual.
Bronchospasm: Intravenous Injection: Adults: 0.25-0.5 mg (0.5-1 mL) is injected slowly intravenously. The solution for injection is diluted with sterile physiological saline up to 10 mL and is given slowly intravenously during 5 minutes. The dose may have to be repeated with short intervals (a few hours). The dose should not exceed 2 mg in 24 hours.
Intravenous Infusion: Adults: 1-2 mg (2-4 mL) is given during a 24 hour interval as a continuous infusion. An initial loading dose up to 0.10 mg (0.2 mL) can be given over 10 minutes.
Children: Up to 25 μg/kg b.w. (0.05 mL/kg b.w.) is given during a 24 hour interval as a continuous infusion. An initial loading dose up to 1.5 μg/kg b.w. (0.003 mL/kg b.w.) can be given over 10 minutes.
Subcutaneous Injection: Adults: 1-2 mg (2-4 mL) is given during a 24 hour interval, split into at least 4 occasions.
Children: Up to 25 μg/kg b.w. (0.05 mL/kg b.w.) is given during a 24 hour interval, split into at least 4 occasions.
Preterm Labour: The dose must be individually titrated. Pulse rate and blood pressure should be carefully monitored during treatment. Initially 5 μg/min could be given as an infusion during 20 minutes. The dose can then be increased by 2.5 μg/min at 20 minute intervals until contractions stop. More than 10 μg/min should seldom be given, and 20 μg/min should not be exceeded. Let the infusion continue for 1 h at the chosen infusion rate, and then decrease the rate of infusion in steps of 2.5 μg/min at 20 minute intervals down to the lowest maintenance dose that produces continued suppression of the contractions. Keep the infusion at this rate for 12 h and then continue with oral maintenance therapy (5 mg x 3).
The oral treatment should be continued until the end of the 36th week of pregnancy. As an alternative treatment, subcutaneous injections (0.25 mg four times in a 24 h period) could be given for a few days before oral treatment is started.
Suggestion for Dilution: 5 mg (2 ampoules of 5 mL) in 1000 mL of dextrose solution or physiological saline. Prepared solution contains 5 μg/mL and should be used within 12 hours. Terbutaline sulfate (BRICANYL) should not be diluted in alkaline solutions. Saline should be avoided during pregnancy since the risk of producing pulmonary edema may increase when this diluent is used in pregnant women. If saline has to be used, the patient should be carefully monitored. Terbutaline sulfate (BRICANYL) can be added to infusion solutions in glass bottles as well as in PVC plastic bags.
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