Brintellix

Brintellix

vortioxetine

Manufacturer:

Lundbeck

Distributor:

Metro Drug
Concise Prescribing Info
Contents
Vortioxetine HBr
Indications/Uses
Major depressive disorder in adult.
Dosage/Direction for Use
Initially 10 mg once daily, may be increased to max of 20 mg or decreased to min of 5 mg once daily. Elderly ≥65 yr Starting dose: 5 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Concomitant w/ nonselective MAOIs or selective MAO-A inhibitors.
Special Precautions
Increased risk of suicidal thoughts, self harm & suicide; serotonin & neuroleptic malignant syndromes. History of seizures or unstable epilepsy; mania/hypomania. Patients taking anticoagulants &/or medicinal products known to affect platelet function & in those w/ known bleeding tendencies/disorders. Discontinue use in patients w/ symptomatic hyponatremia. Monitor for any clinical worsening, suicidal behavior or thoughts & unusual changes in behavior. Severe renal & hepatic impairment. May affect ability to drive & use machines. Pregnancy & lactation. Childn & adolescents <18 yr.
Adverse Reactions
Nausea. Abnormal dreams; dizziness; diarrhoea, constipation, vomiting; pruritus, including generalised pruritus.
Drug Interactions
Risk of serotonin syndrome w/ irreversible non-selective MAOIs; irreversible MAO-B inhibitors (eg, selegiline or rasagiline); serotonergic medicinal products (eg, tramadol, sumatriptan & other triptans); St. John's wort. May lower seizure threshold w/ antidepressants (TCAs, SSRIs, SNRIs) & neuroleptics (phenothiazines, thioxanthenes & butyrophenones), mefloquin, buproprion, tramadol. Increased exposure w/ strong inhibitors of CYP3A4 (eg, itraconazole, voriconazole, clarithromycin, telithromycin, nefazodone, conivaptan & HIV PIs) & CYP2C9 inhibitors (eg, fluconazole & amiodarone). Decreased AUC w/ rifampicin, carbamazepine, phenytoin. Increased risk of bleeding w/ oral anticoagulants or antiplatelet medicinal products. Enhanced effects w/ lithium or tryptophan. Moclobemide; linezolid; strong CYP2D6 inhibitors (eg, bupropion, quinidine, fluoxetine, paroxetine).
MIMS Class
Antidepressants
ATC Classification
N06AX26 - vortioxetine ; Belongs to the class of other antidepressants.
Presentation/Packing
Form
Brintellix FC tab 10 mg
Packing/Price
28's (P1,934/box)
Form
Brintellix FC tab 15 mg
Packing/Price
28's (P3,288.73/box)
Form
Brintellix FC tab 5 mg
Packing/Price
28's (P1,035/box)
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