Brucipro

Ciprofloxacin HCl

Infections including anthrax, biliary tract infections, infected bites & stings, bone & joint infection, cat scratch disease, chancroid, exacerbations of cystic fibrosis, ENT infections (including otitis externa, otitis media & sinusitis), Haemophilus spp, Aggregatibacter spp, Cardiobacterium hominis, Eikenella corrodens & Kingella spp (HACEK) endocarditis, gastroenteritis (including traveler's diarrhea & campylobacter enteritis, salmonella enteritis, shigellosis & yersinia enteritis), gonorrhea, granuloma inguinale, infections in immunocompromised patients (neutropenia), Legionnaire's disease, pelvic inflammatory disease, peritonitis, plague, lower resp tract infections (including pseudomonal infections in cystic fibrosis, but excluding infections due to Strep pneumoniae eg, pneumococcal pneumonia), rickettsial infections (including Q fever, spotted fever & typhus), septicemia, skin infections (including soft-tissue infections), typhoid & paratyphoid fever & UTI including chronic bacterial prostatitis. Prophylaxis for meningococcal meningitis & surgical infection.

Adult 250-750 mg bid. Women w/ acute uncomplicated cystitis 100 mg bid for 3 days. Gonorrhea 250 or 500 mg single dose. Meningococcal meningitis prophylaxis 500 mg single dose. Surgical infection prophylaxis 750 mg single dose given 60-90 min pre-op. Childn & adolescent 5-15 mg/kg bid only if essential.

May be taken with or without food.

Hypersensitivity to ciprofloxacin or other quinolone anti-infectives. Lactation.

Hypersensitivity. Discontinue if symptoms of depression or psychoses leading to self-endangering behavior occur. Crystalluria. Maintain adequate hydration & avoid excessive alkalinity of urine.

GI disturbances including nausea, vomiting, diarrhea, abdominal pain & dyspepsia. Headache, dizziness & restlessness; tremor, drowsiness, nightmares, visual & other sensory disturbances, hallucinations, psychotic reactions, depression, convulsions & intracranial HTN; paresthesia & peripheral neuropathy.

May increase plasma conc of clozapine, ropinirole, theophylline & tizanidine. May enhance effect of oral anticoagulants eg, warfarin & oral antidiabetic glibenclamide. May inhibit renal tubular secretion of methotrexate. Reduced excretion & may increase plasma conc w/ probenecid. Reduced absorption w/ cations eg, Al, Ca, Mg or Fe. Transient increase in serum creatinine w/ ciclosporin. Altered serum conc of phenytoin.

Quinolones

J01MA02 - ciprofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.

Rx