Buformin


Concise Prescribing Info
Indications/Uses
Type 2 DM.
Dosage/Direction for Use
Adult : PO Up to 300 mg/day.
Dosage Details
Oral
Type 2 diabetes mellitus
Adult: Up to 300 mg daily.
Administration
Should be taken with food.
Contraindications
Diabetic coma; ketoacidosis; severe infection; trauma; other severe infections where buformin is unlikely to control the hyperglycaemia; renal or hepatic impairment; heart failure; recent MI; dehydration; alcoholism; conditions likely to predispose to lactic acidosis.
Special Precautions
Stop treatment temporarily 48 hrs before examinations using contrast media. Monitor renal function throughout therapy. Annual monitoring of vit B12 concentrations during long-term treatment.
Adverse Reactions
Anorexia; nausea; diarrhoea; hypoglycaemia; metallic taste; wt loss.
Potentially Fatal: Lactic acidosis.
Drug Interactions
Drugs that may impair renal function. Increased risk of lactic acidosis and hypoglycaemia with alcohol. Other hypoglycaemics; hyperglycaemics.
Action
Description: Buformin delays absorption of glucose from the GI tract, increases insulin sensitivity and glucose uptake into cells and inhibits hepatic gluconeogenesis.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Buformin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in