Butamirate


Generic Medicine Info
Indications and Dosage
Oral
Non-productive cough
Adult: As 50 mg tab: 2 or 3 tabs daily at intervals of 8 or 12 hours. As 7.5 mg/5 mL syr: 15 mL up to 4 times daily.
Contraindications
Children <18 years. 1st trimester of pregnancy.
Special Precautions
Renal and hepatic impairment. Pregnancy (2nd to 3rd trimester) and lactation.
Adverse Reactions
Significant: Somnolence, dizziness.
Gastrointestinal disorders: Diarrhoea, nausea.
Skin and subcutaneous tissue disorders: Urticaria, rash.
Patient Counseling Information
This drug may cause dizziness and somnolence, if affected, do not drive or operate machinery.
Overdosage
Symptoms: Drowsiness, dizziness, nausea, vomiting, diarrhoea, hypotension. Management: Symptomatic treatment. Administer activated charcoal or saline laxative, or perform gastric lavage. Monitor vital functions.
Drug Interactions
Concomitant use of expectorants may lead to retention of mucous in the respiratory system, which can increase the risk of bronchospasm and airway infection.
Action
Description: Butamirate is a non-narcotic antitussive which presents nonspecific anticholinergic and antispasmodic effect, facilitating respiration. It acts centrally by diminishing the tussigenic reflex, and peripherally via a bronchospasmolytic activity enhanced by an anti-inflammatory action.
Pharmacokinetics:
Absorption: Rapidly and completely absorbed from the gastrointestinal tract. Time to peak plasma concentration: Approx 1.5 hours.
Distribution: Plasma protein binding: Approx 95%
Metabolism: Undergoes hydrolysis to phenyl-2-butyric acid and diethylaminoethoxyethanol.
Excretion: Primarily via kidneys as metabolites. Plasma elimination half-life: Approx 13 hours.
Storage
Store below 30°C. Protect from light.
ATC Classification
R05DB13 - butamirate ; Belongs to the class of other cough suppressants.
References
Buckingham R (ed). Butamirate Citrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/08/2018.

Butamirate 7.5 mg/5 mL Syrup (Actavis Group PTC ehf). MHRA. https://products.mhra.gov.uk/. Accessed 07/08/2018.

Sinecod Forte (Novartis Healthcare). MIMS Philippines. https://www.mims.com/philippines. Accessed 12/11/2015.

Disclaimer: This information is independently developed by MIMS based on Butamirate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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