Sodium ascorbate, zinc (sulfate monohydrate).
Each 5 mL contains (teaspoonful): Sodium Ascorbate 112.5 mg (equivalent to 100 mg Ascorbic acid), Zinc (as sulfate monohydrate) 10 mg.
Pharmacology: Pharmacokinetics: Sodium Ascorbate is readily absorbed from gastrointestinal tract and is widely distributed in the body tissues. Plasma concentrations of sodium ascorbate rise as the dose ingested is increased until a plateau is reached with doses of about 90 to 150 mg daily. Body stores of sodium ascorbate in healthy patient are about 1.5 g although more may be stored at intakes above 200 mg daily. The concentration is higher leucocytes and platelets than in erythrocytes and plasma. In deficiency states the concentration in leucocytes declines later and at a slower rate, and has been considered to be a better criterion for the evaluation of deficiency than the concentration in plasma. Sodium Ascorbate is reversible oxidised to dehydroascorbic acid; some is metabolised to ascorbate-2-sulfate which is inactive and oxalic acid which are excreted in the urine. Sodium Ascorbate in excess of the body's needs is also rapidly eliminated unchanged in the urine; this generally occurs within intakes exceeding 100 mg daily. Sodium ascorbate crosses the placenta and is distributed into breast milk. It is removed by haemodialysis.
Vitamin C, a water soluble vitamin, is essential for the synthesis of collagen and intercellular material. Vitamin C deficiency develops when the dietary intake is inadequate. It is rare in adults, but may occur in infants, alcoholics, or the elderly. Deficiency leads to the development of a well-defined syndrome known as scurvy. This is characterized by capillary, fragility, bleeding (especially from small blood vessels and the gums), normocytic or macrocytic anemia, cartilage and bone lesions, and slow healing of wounds. It is used in the treatment and prevention of Vitamin C deficiency.
Doses of 25 to 75 mg daily in the prevention of deficiency, and 250 mg or more daily in divided doses for the treatment of deficiency.
Should be given with care to patients with hyperoxaluria.
Sodium Ascorbate is usually well-tolerated. Large doses are reported to cause diarrhea and other gastrointestinal disturbances. It has also been stated that large doses may result in hyperoxaluria and the formation of renal calcium oxalate calculi and ascorbic acid. Tolerance may be induced with prolonged use of large doses, resulting in symptoms of deficiency when intake is reduced to normal.
Store at temperatures not exceeding 30°C.
A11GB - Ascorbic acid (vitamin C), combinations ; Used as dietary supplements.