Calsate

Calsate

calcium carbonate

Manufacturer:

Millimed

Distributor:

Endure Medical
Full Prescribing Info
Contents
Calcium carbonate.
Description
Each tablet contains: Calcium Carbonate 1.25 g (elemental Calcium 500 mg).
Action
Pharmacology: Pharmacokinetics: Calcium carbonate is converted to calcium chloride by gastric acid. Some of the calcium is absorbed from the intestines and the unabsorbed portion is excreted in the feces.
Indications/Uses
Calcium carbonate is used as calcium supplement in deficiency states and as an adjunct in the management of osteoporosis. It is also used as antacid. It can also be used to treat hyperphosphatemia in patients with chronic renal failure or associated secondary hyperparathyroidism.
Dosage/Direction for Use
Calcium carbonate as an antacid is given in doses of up to about 1.5 g by mouth.
For the purpose of treatment of hyperphosphatemia in patients with chronic renal failure, initial doses of 2.5 g daily by mouth in divided doses have been given, increased up to 17 g daily in divided doses as required.
Doses in infants and children, given 3 to 4 times daily with or before meals, and adjusted as necessary:
1 month to 1 year of age: 120 mg;
1 to 6 years: 300 mg;
6 to 12 years: 600 mg;
12 to 18 years: 1.25 g, or as prescribed by the physician.
Overdosage
Overdose may lead to hypercalcemia. Symptoms of hypercalcemia may include anorexia, thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, fatigue, mental disturbances, polydypsia, polyuria, bone pain, nephrocalcinosis, nephrolithiasis and in severe cases, cardiac arrhythmias. Extreme hypercalcemia may result in coma and death. Persistently high calcium levels may lead to irreversible renal damage and soft tissue calcification.
Contraindications
Calcium carbonate is contraindicated to patients with the following conditions: Hypercalcemia, hypercalciuria; Kidney stones; Long-term immobilization in combination with hypercalciuria and/or hypercalcemia; Nephrocalcinosis; Primary hyperparathyroidism; Myeloma; Bone metastases; Hypersensitivity to the active substance.
Special Precautions
Calcium carbonate can cause hyperkalemia, particularly in patients with renal impairment or after high doses.
Alkalosis may also occur as a result of the carbonate anion. There have been rare reports of the milk-alkali syndrome and tissue calcification.
Use In Pregnancy & Lactation
Pregnancy category: C.
Calcium carbonate can be used during pregnancy. Daily intake should not exceed 2.5 g of calcium as permanent hypercalcemia has been related to adverse effects on the developing fetus.
Calcium carbonate can also be used during lactation. Calcium passes into breast milk at therapeutic doses.
No effect on the breastfed new born are anticipated.
Adverse Reactions
Calcium carbonate may occasionally cause constipation. Flatulence from released carbon dioxide may occur in some patients. High doses or prolonged use may lead to gastric hypertension and acid rebound.
Drug Interactions
Calcium salts interact with many other drugs both by alterations in gastric pH and emptying, and by formation of complexes that are not absorbed. Interactions can be minimized by giving calcium carbonate and any other medication 2 to 3 hours apart.
Storage
Store at temperatures not exceeding 30°C.
ATC Classification
A12AA04 - calcium carbonate ; Belongs to the class of calcium-containing preparations. Used as dietary supplements.
A02AC01 - calcium carbonate ; Belongs to the class of calcium-containing antacids.
Presentation/Packing
Tab 500 mg (white, oblong, biconvex tablets, with engraved "1250" on one side) x 50's.
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