Cardomin Special Precautions







Full Prescribing Info
Special Precautions
Dobutamine should not be given through same IV line as heparin, hydrocortisone sodium succinate, cefazolin or penicillin.
Dobutamine must be diluted prior to use.
Hypovolemia should be corrected prior to use; infiltration causes local inflammatory changes.
Extravasation may cause dermal necrosis.
Dobutamine, a potent drug, should be used with extreme caution following myocardial infarction.
In patients with marked mechanical obstruction eg, severe valvular stenosis, Cardomin may be ineffective and potentially harmful.
Safety and efficacy of dobutamine or other cyclic adenosine monophosphate (AMP)-dependent inotropic agents in the long-term treatment (exceeding 48 hrs) of patients with congestive heart failure has not been established.
In doses that produce similar cardiac output, dobutamine produces less increase in heart rate, less decrease in peripheral resistance and less decrease in diastolic blood pressure than isoproterenol.
Use in pregnancy & lactation: Dobutamine should be used in pregnancy only if clearly needed. The effect of dobutamine on labor and delivery is not known.
It is not known whether dobutamine is distributed in human milk; since many drugs are excreted in breast milk, caution should be exercised when dobutamine is administered to a nursing woman. If a nursing woman requires dobutamine therapy, breastfeeding should be discontinued for the duration of drug therapy.
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