Body as a Whole: Asthenia, allergy, fatigue, fever, hypovolemia, malaise, edema (generalized, peripheral, dependent, genital, leg, hypervolemia, fluid overload), flu syndrome, pain in extremities.
Cardiovascular: Bradycardia, hypotension/postural hypotension, fluid overload, syncope (including presyncope), AV block, palpitation, angina pectoris (including chest pain), cardiac failure, hypertension, peripheral ischemia, tachycardia, bundle branch block, myocardial ischemia, peripheral circulation disturbances (eg, cold extremities, peripheral vascular disorder, exacerbation of intermittent claudication, Reynaud's phenomenon).
Gastrointestinal: Diarrhea, nausea, vomiting, melena, periodontitis, gastrointestinal pain, abdominal pain, bilirubinemia, dry mouth, gastrointestinal hemorrhage, constipation.
Hematologic: Prolongation of prothrombin time, purpura, thrombocytopenia, anemia, leukopenia, pancytopenia, atypical lymphocytes, aplastic anemia (rare).
Metabolic and Nutritional: Hyperglycemia, hypoglycemia, hyperuricemia, hyponatremia, hypercholesterolemia, hyperkalemia, hypokalemia, hypertriglyceridemia, glycosuria, weight increase, weight loss, diabetes mellitus, gout; Elevations of the following: alkaline phosphatase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transferase (GGT), blood urea nitrogen (BUN), non-protein nitrogen (NPN), creatinine; decreased high-density lipoprotein.
Musculoskeletal: Arthralgia, arthritis, hypotonia, muscle cramps.
Nervous: Dizziness, headache, hypesthesia, vertigo, somnolence, paresthesia, cerebrovascular accident, depression, hypokinesia, nervousness, sleep disorder, impaired concentration, abnormal thinking, paroniria, emotional lability, cerebrovascular disorder, convulsions, migraine, neuralgia, paresis, amnesia.
Reproductive (Male): Impotence, decreased libido.
Respiratory: Increased cough, rales, dyspnea, lung edema, asthma, bronchospasm, bronchitis, pneumonia, upper respiratory tract infection, pulmonary edema, wheezing, stuffy nose, respiratory alkalosis, interstitial pneumonitis (rare).
Skin and Appendages: Pruritus, rash (erythematous, maculopapular, psoriaform), allergic exanthema, photosensitivity reaction, increased sweating, anaphylactoid reaction, angioedema, urticaria, exfoliative dermatitis, dermatitis, severe skin reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme (rare).
Special Senses: Abnormal or blurred vision, eye irritation, decreased lacrimation, tinnitus, decreased hearing.
Urogenital: Abnormal renal function, renal failure, albuminuria, hematuria, increased micturition frequency, urinary tract infection, urinary incontinence in women (rare).
Class Effect: Due to β-blocking properties, it is possible for latent diabetes mellitus to become manifest, manifest diabetes to be aggravated, and blood glucose counter-regulation to be inhibited.